Idra-21 kognitívny prášokje pozitívny alosterický regulátor AMPA receptora a derivát benzotiadiazolu. Je to chirálna molekula, v ktorej ( plus ) - IDRA-21 je aktívna forma.
Ako sa IDRA-21 správala pri pokusoch na zvieratách?
Pri štúdiu podpory inteligencie u zvierat,prášok IDRA-21výrazne zlepšila schopnosť učenia a pamäte. Pri zvrátení kognitívnych deficitov spôsobených{0}}dlhodobým užívaním alprazolamu alebo skopolamínu je asi 10-30-krát silnejší ako aniracetam. Najúžasnejšia vec je doba metabolizmu liečiva: bolo študované, že má trvalé účinky trvajúce až 48 hodín po jednorazovom podaní. Vedci tvrdia, že mechanizmus tohto účinku pravdepodobne spočíva v podpore dlhodobého zlepšovania medzi mozgovými synapsiami.
Aký je proces skúmania drog na zlepšenie kognitívnych funkcií? Ako boloIDRA-21narodený?
In 1990, neuroscientist Eric Kandel discovered a brain chemical called cyclic adenosine monophosphate response element-binding protein (CREB), which is a key factor in memory formation. In 1994, neuroscientists Tim Tully and Jerry Yin adjusted the way CREB works in a fruit fly. When learning new habits, fruit flies with enhanced CREB were 10 times faster than their unchanged counterparts. Later, other researchers got the same results in mice. In 1999, Qian Zhuo, a neuroscientist at Princeton University, created a mouse with more pairs of NR2B genes, which can coordinate the activity of synaptic receptors in the brain. In memory and learning tests, NR2B enhanced mice performed five times better than unmodified mice. After 2000, many new pharmaceutical companies competed to apply these findings to humans. Both memory pharmaceutical and helikongshan medical are conducting clinical trials of drugs related to CREB. Another COLTEX pharmaceutical company is developing a brain chemical called ampakine to achieve similar effects through another neural pathway. Among so many research institutions, Jingsi pharmaceutical （Abbreviation: IDRA） has developed IDRA-21 through step-by-step analogy research. At the same time, there are many sister products of this product, which have been eliminated for various reasons.